Ray Peat on ammonia
"If we eat seeds in the crude form, our digestive enzymes handle the glutin differently, producing some fairly toxic peptides (chemically related to histamine) and some ammonia; these, added to the starch, can cause gas and a variety of allergic reactions"
- Nutrition For Women
0 upvotes"Besides this fundamental stabilizing, regulatory function of carbon dioxide, it combines with ammonia to form urea. Urea, like carbon dioxide, powerfully contributes to the regulation of water, modifying its properties. The elimination of ammonia protects against its toxic effects, which include creating pseudohypoxia,"
- March 2020 - Ray Peat's Newsletter
0 upvotes"In hypothyroidism, with lowered oxidative metabolism, the organism is never far from stress and hyperventilation, with the chronic production of lactate and ammonia. The inefficient metabolism of diabetes has similar effects."
- July 2017 - Ray Peat's Newsletter
0 upvotes"Besides ammonia and lactate, other stress related substances can also increase the drive to breathe more, depleting the essential CO2—endotoxin, acetylcholine, serotonin, hydrogen sulfide, nitric oxide, carbon monoxide, angiotensin, and estrogen, for example."
- July 2017 - Ray Peat's Newsletter
0 upvotes"Hypothyroid people, with low production of CO2, are very susceptible to stress-induced hyperventilation, and they are often in a state of physiological hyperventilation. They are susceptible to over-production of ammonia (De Nardo, et al., 1999; Marti, et al., 1988) and lactate (Zarzeczny, et al., 1996), and to psychosis, especially depression and mania."
- July 2017 - Ray Peat's Newsletter
0 upvotes"Energy deprivation, caused by insufficient glucose or oxygen, causes immediate swelling of cells, and is associated with excitation; the ammonia associated with energy deprivation and excess excitation contributes to swelling"
- July 2017 - Ray Peat's Newsletter
0 upvotes"Glucose deprivation, by causing glutamine to be used as fuel, increases the formation of ammonia, and ammonia (through an excitatory effect on cells and direct activation of enzymes) promotes the glycolytic use of glucose, producing lactic acid even in the presence of oxygen and perpetuating the scarcity of glucose."
- July 2017 - Ray Peat's Newsletter
0 upvotes"Stress modifies our breathing, causing a vicious cycle, in which the lactate and ammonia produced when stimulation exceeds our oxidative capacity stimulate more intense breathing, causing more carbon dioxide to be lost, reducing oxidative efficiency and increasing the formation of ammonia and lactate."
- July 2017 - Ray Peat's Newsletter
0 upvotes"Because of their role in producing and maintaining pseudohypoxia, and stimulating hyperventilation, there should be more attention to measuring the presence of ammonia and lactate in the blood, breath and urine."
- July 2017 - Ray Peat's Newsletter
0 upvotes"The doctrine of hypocalcemic tetany led to the practice of treating tetany with intravenous calcium solutions; for example, veterinarians often treat cows’ grass tetany with large intravenous doses of calctum. The treatment works, but the tetany is now attributed to a magnesium deficiency (since magnesium supplementation works better, as Koch discovered), and excessive ammonia produced in the cow’s rumen can contribute to the magnesium deficiency."
- 1999 - December- Ray Peat's Newsletter
0 upvotes"Koch found that the convulsions produced by removal of the parathyroid glands were associated with the development of nephritis and the appearance of the toxic substances, guanidine and miethylguanidine. These compounds, and ammonia, are now known to produce convulsions by acting on the excitatory amino acid receptors"
- 1999 - December- Ray Peat's Newsletter
0 upvotes"Ammonia, in chronic poisoning, rather producing convulsions, produces stupor and coma, and at this point, its combination with glutamic acid to produce glutamine is probably important as a defense against seizures, eliminating both ammonia and glutamic acid."
- 1999 - December- Ray Peat's Newsletter
0 upvotes"Carbon dioxide reacts spontaneously with ammonia, and with other amines. The reaction of ammonia with carbon dioxide is the first step in the formation of urea, protecting against the potential toxicity of ammonia."
- 1998 - Ray Peat's Newsletter - 3
0 upvotes"For several years, I have been interested in the biological effects of ammonia, and compounds that are metabolically close to it. There is clear evidence of ammonia’s antiviral effect, which stimulated extensive research by drug companies seeking patentable antiviral amines. Most simple substances have regulatory functions in themselves, besides participating in other systems. Besides viral immunity, I think ammonia is involved in regeneration and nerve modulation. Urea, inosine, GABA, the polyamines, and betaine derivatives (e.g., gamma-butyrobetaine) are closely related to ammonia metabolism, and combinations of them will probably have many useful biological effects."
- 1991 - July - Ray Peat's Newsletter
0 upvotes"Orotic acid was known to alter pyrimidine and ammonia metabolism, so I thought it wasn’t wise to use supplements that contained large amounts of it. A couple of years ago orotic acid was described as an excellent liver carcinogen, based on experiments with rats. h"
- 1990 - May - - Ray Peat's Newsletter
0 upvotes"Since carbon monoxide binds to metal atoms, it might be held in a form which reacts easily with ammonia. Then during stress, which causes both lipid peroxidation and ammonia formation, rhodanese would be needed to protect the respiratory cytochromes from the cyanide, which would otherwise inhibit respiratory energy production, and other processes involving the cytochromes."
- 1989 - January - Ray Peat's Newsletter
0 upvotes"Stress also leads to the production of intracellular toxins, including ammonia and carbon monoxide, which tend to perpetuate the blocked state."
- 1988 - August.September - Ray Peat's Newsletter
0 upvotes