Ray Peat on aspirin

Nutritional Adjustments Required for Various Drugs Including Estrogen

"Any drug alters your nutritional needs. Tobacco, iron, aspirin, estrogen, tranquilizers and diuretics must be taken into account. There are special diets for special needs."

- Nutrition For Women

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Standard Atrial Fibrillation Treatment Versus Thermogenic Agents

"The standard treatment for atrial fibrillation is destruction of part of the conduction system of the heart, called ablation, which costs more than $25,000 in the U.S., and results in a very high percentage of heart failure. Correction of the problematic prolonged QT interval with thermogenic agents such as progesterone, thyroid, and aspirin (Korkmaz-Icéz, et al., 2016) isn’t of interest to the profession."

- November 2020 - Ray Peat's Newsletter

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Aspirin's Role in Mitochondrial Oxygen Consumption and Fever

"Probably because of aspirin’s anti-fever effect, the medical culture tends to think of it as antithermogenic, despite its known stimulation of mitochondrial oxygen consumption. Like thyroid hormone, aspirin prevents stress-induced loss of sodium, which is an important part of our temperature and energy regulating system."

- November 2020 - Ray Peat's Newsletter

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Compounds That Mitigate Carbon Monoxide's Adverse Effects

"Safe things that lower carbon monoxide or protect against its effects include methylene blue, caffeine, aspirin, progesterone, and red light."

- November 2017 - Ray Peat's Newsletter

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Anti-Inflammatory Treatments for New Corona Virus Response

"In reaction to the new corona virus, a few groups responded quickly, treating successfully with antiinflammatory things—losartan, cinanserin (a serotonin antagonist), aspirin, and azithromycin or erythromycin, which lower intracellular calcium. Aspirin’s effects overlap those of losartan, and it downregulates the angiotensin receptor, ATR1"

- May 2020 - Ray Peat's Newsletter

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Factors for Healthier Pregnancies and Postpartum Life

"the most important factors that can be optimized with existing resources. Healthier pregnancies will result in healthier and happier postpartum life. Some of these factors would be sunlight, vitamin D, milk, cheese, eggs, fruits and well cooked vegetables, fibrous foods, and optimizing thyroid function and pregnenolone and progesterone (which support mitochondrial function, protecting against aldosterone, parathyroid hormone, excess serotonin, CRK, and cortisol, besides increasing allopregnanolone), and using the safest antiinflammatory and antiserotonin drugs, such as aspirin and cyproheptadine, when they are needed."

- May 2019 - Ray Peat's Newsletter

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Oxidative Processes and Enzyme Regulation Factors

"The oxidative processes that support purposive, creative functioning of the organism, optimize CO2 by inhibiting carbonic anhydrase; this enzyme is inhibited by thyroid hormone T3, progesterone, urea, caffeine, antipsychotic drugs, and aspirin. Agents that tend to cause reversion to the primitive anaerobic energy production activate the enzyme—serotonin, tryptophan, cysteine, histamine, estrogen, aldosterone, HIF, SSRIs, angiotensin, and parathyroid hormone, for example."

- March 2020 - Ray Peat's Newsletter

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Fundamental Substance Combinations Over Specific Ailment Drugs

"Combinations of substances such as CO2, progesterone, angiotensin receptor blockers, acetazolamide and aspirin that affect fundamental properties of the organism are appropriate for use in a great range of problems now treated with drugs considered to be specific for particular ailments. The purpose should be to support the patient’s recovery, not to eliminate a disease."

- March 2020 - Ray Peat's Newsletter

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Aspirin and Progesterone's Role in Combating Insomnia

"Using aspirin at bedtime, to inhibit prostaglandin synthesis, is likely to be helpful in age related insomnia. Progesterone and vitamin E act in various ways to prevent excessive stimulation by prostaglandins."

- March 2018 - Ray Peat's Newsletter

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Neuroprotective Effects of Caffeine, Aspirin, Melatonin

"caffeine, aspirin, and melatonin protect the substantial nigra against rotenone"

- March 2017 - Ray Peat's Newsletter

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Protective Factors in Parkinson’s Broadly Counteract Estrogen

"things that are likely to be protective in Parkinson’s disease are broadly protective against estrogen and the inflammatorydegenerative processes: Progesterone, minocycline and other anti-inflammatory antibiotics, agmatine, aspirin, coffee, niacinamide, citrus flavonoids, vitamin D, ACE inhibitors, fibrous-antiseptic foods."

- March 2017 - Ray Peat's Newsletter

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List of Various Medications and Supplements

"Acetazolamide, agmatine, amantadine, aminoguanidine, antibiotics (minocycline, tetracycline, etc.), antihistamines, aspirin, bromocriptine, DCA, emodin, glucagon, glucose, memantine, methylene blue, niacinamide, T3 (triiodothyroinne), vitamin D, vitamin E."

- March 2016 - Ray Peat's Newsletter

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Mitigating Excessive Serotonin's Harmful Effects

"Avoiding prolonged fasting and stressful exercise that increase free fatty acids, and combining sugars with proteins to keep free fatty acids low, and using aspirin, niacinamide, or cyproheptadine to reduce the formation of free fatty acids by unavoidable stress, avoiding an excess of phosphate relative to calcium in the diet, having milk and other antistress foods at bedtime or during the night, and being in a brightly lighted environment during the day, with regular sunlight exposure, can minimize the harmful effects of excessive serotonin and reduce the inflammation, fibrosis, and atrophy associated with it."

- July 2019 - Ray Peat's Newsletter

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The Controversy Surrounding Aspirin in Medical Fields

"Aspirin is just one of many cheap generic substances that have been attacked frequently in the medical journals."

- July 2018 - Ray Peat's Newsletter

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Aspirin and Inflammation: The Lesser-Known Pro-Oxidant Effect

"The fact that the inflammation-promoting enzymes, aromatase, cyclooxygenase, and nitric oxide synthase, which are inhibited by an oxidizing environment are also inhibited by aspirin, would strongly suggest that aspirin and salicylic acid are functioning as pro-oxidants."

- July 2016 - Ray Peat's Newsletter

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Combatting Oxidative Damage with Aspirin and Bioflavonoids

"xidative damage, such as lipid peroxidation, is a seriously harmful phenomenon. Aspirin and the bioflavonoids are powerfully protective against lipid peroxidation and the DNA mutations and protein damage triggered by the most toxic free radical, the hydroxyl radical."

- July 2016 - Ray Peat's Newsletter

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Defense Mechanisms Against Nitric Oxide: The Nutritional Angle

"Some of the most important anti-nitric oxide defenses are progesterone, vitamin E, vitamin K, vitamin A, niacinamide, coffee, aspirin, and foods containing flavonoids, terpenoids, polyphenols, and sterols. Grass-fed milk contains a variety of polyphenols. Citrus fruits, many tropical fruits (e.g., guavas, longans, and lychees), and cooked mushrooms are good sources of apigenin, naringenin and related chemicals."

- January 2016 - Ray Peat's Newsletter

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Aspirin's Increased Vitamin K Requirement

"aspirin makes you need more vitamin K, even when you arent using much. People who use aspirin for arthritis or cancer often take several grams a day."

- Email Response by Ray Peat

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Germicidal Properties of Aspirin

"Aspirin has a mild germicidal effect."

- Email Response by Ray Peat

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Reducing Aspirin's Stomach Reactions

"I dont know anyone who has a stomach reaction when they dissolve the aspirin in hot water, and then take it with food."

- Email Response by Ray Peat

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Prostaglandins in Cancer and Aspirin's Therapeutic Potential

"The prostaglandins were discovered in prostatic fluid, where they occur in significant concentrations. They are so deeply involved with the development of cancers of all sorts that aspirin and other prostaglandin inhibitors should be considered as a basic part of cancer therapy."

- 1998 - May Ray Peat's Newsletter

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