Ray Peat on carbon monoxide
"If toxins such as CO and NO are beneficial, hormetically, when they occur in city air, then obviously they must be very beneficial when they are produced in the body by enzymes, which evolved through the natural selection of things that supported survival—there is a clear Panglossian aspect to neodarwinism, everything exists because of its fitness."
- November 2017 - Ray Peat's Newsletter
0 upvotes"Part of the basic cellular defense reaction involves enzymes that process toxins in ways that improve the immediate situation, but that can create new problems for the organism if they become chronic. For example, stressed tissues produce carbon monoxide and estrogen, which prevent apoptosis and promote autophagy, with short-term survival value. Surviving in the stressed condition under the influence of CO and estrogen, the cells produce cytokines that affect the sensitivity of surrounding cells to stress and inflammation, and progressively undergo epigenetic changes, tending to become cells of a different type,"
- November 2017 - Ray Peat's Newsletter
0 upvotes"‘When carbon monoxide is produced in stress, the breakdown of the heme molecule also releases iron, and biliverdin, which is quickly turned into bilibrubin. Increases of bilirubin and carbon monoxide in the body fluids or breath can be seen in many chronic conditions, along with changes in tissue iron content."
- November 2017 - Ray Peat's Newsletter
0 upvotes"Safe things that lower carbon monoxide or protect against its effects include methylene blue, caffeine, aspirin, progesterone, and red light."
- November 2017 - Ray Peat's Newsletter
0 upvotes"Some people studying autism have found that animals exposed to carbon monoxide have some of the behaviors of autistic children"
- November 2017 - Ray Peat's Newsletter
0 upvotes"One of the anti-respiratory substances produced by estrogen is carbon monoxide (Tschugguel, et al., 2001). Another inhibitor of mitochondrial oxidation, hydrogen sulfide, is also increased by estrogen (Lechuga, et al., 2015)."
- January 2016 - Ray Peat's Newsletter
0 upvotes"Histamine release, nitric oxide, and carbon monoxide are broadly involved in excitotoxic damage, and carbon dioxide tends to be protective against these, too."
- 1999 - December- Ray Peat's Newsletter
0 upvotes"People studying lipid peroxidation in liver cell extracts noticed that carbon monoxide was being produced. Many people have observed that stressed cells emit ammonia."
- 1989 - January - Ray Peat's Newsletter
0 upvotes"Since carbon monoxide binds to metal atoms, it might be held in a form which reacts easily with ammonia. Then during stress, which causes both lipid peroxidation and ammonia formation, rhodanese would be needed to protect the respiratory cytochromes from the cyanide, which would otherwise inhibit respiratory energy production, and other processes involving the cytochromes."
- 1989 - January - Ray Peat's Newsletter
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