Ray Peat on gaba
"Magnetic fields presumably act biologically by acting on the structure of water, and Kholodov has established that a continuous sinusoidal magnetic field has a sedative and inhibiting effect, modifying the EEG and raising the level of GABA in the brain (Speranskiy, 1973). The activity of oxygen increases in magnetically treated water (Speranskiy, 1973), so there might be a direct effect on energy production."
- Mind And Tissue Russian Research Perspectives on the Human Brain
0 upvotes"here are several systems that oppose the toxic effects of adrenalin. GABA, dopamine, and adenosine have multiple anti-adrenergic effects. In many situations, the parasympathetic system is protective against adrenalin. The protective steroids also act at many levels. Magnesium, retained in the ce)l largely under the influence of ATP and thyroid, is our basic calcium blocker, or calcium antagonist. GABA and dopamine inhibit the ACTH-glucccorticoid system, and shift the steroid balance toward the protective anti-glucocorticoids, progesterone, testosterone, pregnenolone, and DHEA."
- 1992 - June - Ray Peat's Newsletter
0 upvotes"Meerson’s laboratory has studied the anti-stress and anti-adrenalin effects of GABA and its metabolite, gamma-hydroxy butyrate, especially in the form of the lithium salt. (Lithium seems to have its own antj-stress effect, probably partly as a sodium agonist, and partly through its ability to complex with the ammonium which is produced in the brain in fatigue, which is exactly when the GABA system becomes active.) GHB is protective against stress damage to many tissues. It prevents stress-induced enzyme leakage from tissues, ulceration of the gastric mucosa, lipid peroxidation, epileptic seizure, damaged contractile function of the heart, and cardiac arrhythmias produced by stress or ischemia."
- 1992 - June - Ray Peat's Newsletter
0 upvotes"The main inhibitory transmitter substance in the brain is GABA (gamma amino butyric acid), which is closely related to aspartic and succinic acids. GABA has many anti-stress effects, besides the direct brain quieting action. For example, it causes a sequestration of insulin, keeping some sugar from being turned into fat, and it promotes progesterone formation, which protects many systems from damaging hyperactivity."
- 1991 - January - Ray Peat's Newsletter
0 upvotes"Camphor, progesterone, nutritional supplements, and artificial fever have even fewer side-effects than penicillin and should be tested more widely. Th GABA analogs, besides being non-toxic, have the additional advantage of being very cheap. In the pharmaceutical bureaucratic world, though, this has too often been a fatal defect."
- 1988 - June - Ray Peat's Newsletter
0 upvotes