Ray Peat on Hans Selye
"Hans Selye found that the adrenals are a major component of our adaptive system. In the first phase of stress, there is a shock reaction (with changes resembling those of estrogen dominance), with injury to various tissues. In the second phase, the adrenals protect the animal, and this protection continues until something is exhausted. By exposing rats to a preliminary stress, Selye found that he could induce adaptation to other, later stresses — a kind of immunization to stress."
- Nutrition For Women
0 upvotes"According to Hans Selye, activation or injury of tissue is the beginning of stress. The more cells involved, the greater is the stress. An injury to a leg connected only by blood vessels produces a stress reaction in the animal, so the signal of stress can be transmitted in the blood, though the nerves are normally also involved. Adenine nucleotides have been suspected as a cause of shock (because they are vasodilators, as are many other products of stress, including phosphate), but other possibilities are histamine, various polyamines, and low blood sugar."
- Nutrition For Women
0 upvotes"Selye divides stress into three phases: alarm, resistance (or adaptation), and exhaustion. Three tissues are usually the first to show effects: thymolymphatic tissue shrinks, gastrointestinal tissue becomes inflamed and bleeds, and the adrenal cortex becomes enlarged."
- Nutrition For Women
0 upvotes"Selye classifies steroids into anti- and proinflammatory. Inflammation is a relatively non-specific, and hopefully local, reaction, serving to isolate the problem if it is a toxin or infection. Cortisol is a typical antiinflammatory hormone;"
- Nutrition For Women
0 upvotes"Hans Selye sometimes used an injected metal, such as iron salts, to experimentally sensitize animals to stress, making it easier to produce arthritis. He found that vitamin E could offset this effect of iron."
- Nutrition For Women
0 upvotes"Stress consumes steroids and produces the many degenerative diseases described by Hans Selye. The gastro-intestinal system becomes inflamed or ulcerated, and fibrous tissue may proliferate. Adrenal glands enlarge, and lymphoid tissue shrinks during the first stage of stress (and may enlarge later)."
- Nutrition For Women
0 upvotes"Hans Selye has demonstrated that vitamin C can prevent heavy metal (e.g., mercury) toxicity; it reduces the metal to a less toxic form, and also helps solubilize and remove it."
- Nutrition For Women
0 upvotes"While the effects of stress on the intestine have been recognized since Hans Selye described the general adaptation syndrome (with intestinal bleeding as an early sign of stress), that hasnt been taken into account in any of the large brain trauma or stroke studies."
- March 2016 - Ray Peat's Newsletter
0 upvotes"Hans Selye was observing the reaction to a small glass tube inserted under a rats skin. He noticed that the tube was soon enclosed by a capsule of fibrous tissue, and that the cells gradually grew in a strand from the ends down the channel of the tube. These cells were isolated from the fluids that normally surround cells, and Selye found that after a short time they took on the appearance of cells from a very old animal, while the cells of the surrounding capsule remained normal. Selye drained the fluid at intervals, allowing it to be replaced by fresh fluid, and found that at the end of the rats life-span, the cells of this filament showed no signs of aging."
- 1995 - September Ray Peat's Newsletter
0 upvotes"Around 1940, Hans Selye found that estrogen’s systemic effect mimics the shock phase of the stress reaction. In shock, deficient circulation of blood and thus deficient oxygenation of tissue are the main problem, and Selye considered the adrenal steroids to be crucial in resolving the problem, and creating adaptation to the stress."
- 1991 - July - Ray Peat's Newsletter
0 upvotes"Hans Selye pointed out that estrogen treatment mimics the first, shock phase of the stress reaction. An excess of estrogen (or any stressor) causes the pituitary to secrete prolactin and ACTH, and both of these hormones act on the ovaries to stop progesterone production,"
- 1990 - October - Ray Peat's Newsletter
0 upvotes"Pregnenolone and progesterone have a vitamin A-sparing effect, besides their direct protective action for the thymus, and they also have the very general protective action which Selye called catatoxic. Both of these hormones have been effectively used to treat various autoimmune ailments. They tend to raise the body temperature and metabolic rate, yet they are anti-catabolic."
- 1989 - November - Ray Peat's Newsletter
0 upvotes