Ray Peat on high altitude
"In one study (Alhazmi, et al., 2018), T3 was four and a half times higher in people living at a high altitude, T4 was about three times higher, and TSH (a promoter of inflammation) was reduced by more than 25%. The high altitude studies show very convincingly that a high metabolic rate is strongly associated with greater longevity and better health."
- November 2020 - Ray Peat's Newsletter
0 upvotes"Altitude and a milk based diet are obviously two important thermogenic factors that slow the accumulation of harmful adaptations, but there are many other controllable factors that could extend longevity even more. Reducing inflammatory factors is important, and personal choices can make a big difference, for example choosing easily digestible foods to reduce endotoxin, avoiding the polyunsaturated fatty acids that interfere with cell respiration and form inflammatory prostaglandins, avoiding antioxidant supplements that create a reductive excess, and choosing foods that contain antiinflammatory-thermogenic compounds, such as citrus fruits with their high content of flavonoids that support cell respiratory functions."
- November 2020 - Ray Peat's Newsletter
0 upvotes"The changes Meersons group has seen in high altitude therapy resemble the changes that occur during supplementation with thyroid and antioxidants. The lower concentration of oxygen in tissues at high elevation would increase the antioxidant reserves of the organism, making it more resistant to stress. Decreasing the use of dietary unsaturated fats similarly protects against oxidative stress."
- Mind And Tissue Russian Research Perspectives on the Human Brain
0 upvotes"Pre-existing inflammation is associated with high altitude sickness and the ability to get sick from a corona virus, as well as chronic diseases."
- May 2020 - Ray Peat's Newsletter
0 upvotes"using calcium channel blockers and acetazolamide to treat the new disease, because of their therapeutic effect in high altitude pulmonary edema. He didn’t mention it, but both of these drugs can correct the tissue deficiency of carbon dioxide."
- May 2020 - Ray Peat's Newsletter
0 upvotes"At low altitude, when a tissue’s oxygen consumption increases beyond the blood’s ability to deliver oxygen, as in an intensely working muscle, the tissue activates the glycolytic process, converting glucose to lactic acid as a source of additional energy."
- May 2020 - Ray Peat's Newsletter
0 upvotes"Neglecting the role of carbon dioxide in suppressing the formation of lactic acid, they also neglect all of its other essential metabolic effects, including its role as the factor whose absence results in the syndromes of altitude sickness,"
- May 2020 - Ray Peat's Newsletter
0 upvotes"The basic principles of respiration, the Bohr and Haldane effects, describe the physical equilibria of oxygen and CO2 in people who have adapted to living at different altitudes. The Haldane effect describes the fact that increased oxygen pressure decreases the amount of carbon dioxide retained by hemoglobin, and decreased oxygen pressure increases the amount of CO2 retained. A steady increase of retained CO2 with increasing altitude occurs in those who adapt. People who fail to adapt experience a loss of CO2, with an increase of lactate."
- May 2020 - Ray Peat's Newsletter
0 upvotes"Calcium channel blockers, paralleling that effect of CO2, are effective treatments for high altitude pulmonary hypertension."
- May 2020 - Ray Peat's Newsletter
0 upvotes"Like acetazolamide, the other recognized treatment for altitude sickness, calcium channel blockers inhibit carbonic anhydrase, facilitating the body’s retention of CO2."
- May 2020 - Ray Peat's Newsletter
0 upvotes"An increased amount of nitric oxide in the exhaled breath is a clear predisposing factor for high altitude sickness"
- May 2020 - Ray Peat's Newsletter
0 upvotes"For several decades high altitude physiologists have been perplexed by what they call the lactate paradox, the fact that exercise at high altitude, with less oxygen, produces less increase in lactic acid in the blood than it does at sea level, allowing quicker recovery, since it is understood that it is oxidative metabolism that prevents the formation of lactic acid—the lower oxygen availability should lead to a higher lactate content at high altitude, and slower recovery."
- March 2020 - Ray Peat's Newsletter
0 upvotes"The loss of carbon dioxide reduces brain circulation, creating complex paresthesias and stroke symptoms. Hyperventilation is a relative term, and refers to the amount of carbon dioxide which is lost from the blood. Heavy, rapid breathing at high altitude or in the presence of a carbon dioxide-rich atmosphere, doesn’t necessarily constitute hyperventilation."
- 1999 - December- Ray Peat's Newsletter
0 upvotes"Carbon dioxide limits the electrical depolarization of nerves and muscles, a phenomenon first discovered by Gilbert Ling. This prevents the over-excitation and exhaustion of brain cells and muscle cells, including the heart. The presence of carbon dioxide limits the formation of lactic acid. This explains the lactate paradox of high altitude exertion"
- 1999 - December- Ray Peat's Newsletter
0 upvotes"Under all conditions studied, the characteristic lactic acid metabolism of stress and cancer is suppressed at high altitude, as resptration is made more efficient. The Haldane effect shows that carbon dioxide retention 1s increased at high altitude."
- 1998 - Ray Peat's Newsletter - 2
0 upvotes"Comparing very low altitude (Jordan valley, over 1000 feet below sea level) with moderate altitude (620 metérs above sea level), ACTH was increased tn runners after a race only at the low altitude, indicating that the stress reaction was prevented by a moderate increase of altitude."
- 1998 - Ray Peat's Newsletter - 2
0 upvotes"It has been found that, during intense exercise (which always produces a lactic acid accumulation in the blood), a lower peak accumulation of lactate occurs at high altitude, and this seems to be caused by a reduction in the rate of glycolysis, or glucose consumption."
- 1997 - Ray Peat's Newsletter
0 upvotes