Ray Peat on histamine
"The great majority of the body’s serotonin is produced in the intestine, where the tissue is constantly exposed to foreign material such as endotoxin, but all cells in the body can produce serotonin and histamine during stress, and the blood platelets are one of the body’s defenses against serotonin; they can sequester it and carry it to the lungs for destruction. The lungs have a great capacity to oxidize it."
- September 2019 - Ray Peat's Newsletter
0 upvotes"Phosphate, which predominates in grains, beans, nuts, meats, and fish, increases our production of parathyroid hormone, while calcium and magnesium inhibit its production. This hormone, which increases with age, suppresses immunity, and in excess it causes insomnia, seizures, dementia, psychosis, cancer, heart disease, respiratory distress and pulmonary hypertension, osteoporosis, sarcopenia, histamine release, inflammation and soft tissue calcification, and many other problems."
- September 2017 - Ray Peat's Newsletter
0 upvotes"According to Hans Selye, activation or injury of tissue is the beginning of stress. The more cells involved, the greater is the stress. An injury to a leg connected only by blood vessels produces a stress reaction in the animal, so the signal of stress can be transmitted in the blood, though the nerves are normally also involved. Adenine nucleotides have been suspected as a cause of shock (because they are vasodilators, as are many other products of stress, including phosphate), but other possibilities are histamine, various polyamines, and low blood sugar."
- Nutrition For Women
0 upvotes"If we eat seeds in the crude form, our digestive enzymes handle the glutin differently, producing some fairly toxic peptides (chemically related to histamine) and some ammonia; these, added to the starch, can cause gas and a variety of allergic reactions"
- Nutrition For Women
0 upvotes"The stimulation of CRH production by histamine, serotonin, endorphins, IL-1, nitric oxide, and/or estrogen in good health leads to the activation of complex and appropriate antistress reactions. When stress is very intense or prolonged, or if nutrition hasn’t been adequate, all of the activating signals, CRH itself, and the antistress glucocorticoids, can produce effects that aren’t integrated into the organism’s functions as it confronts its problems, and that produce symptoms and, eventually, degenerative processes and aging. That failure of integration is almost always the result of insufficient metabolic energy."
- May 2019 - Ray Peat's Newsletter
0 upvotes"The oxidative processes that support purposive, creative functioning of the organism, optimize CO2 by inhibiting carbonic anhydrase; this enzyme is inhibited by thyroid hormone T3, progesterone, urea, caffeine, antipsychotic drugs, and aspirin. Agents that tend to cause reversion to the primitive anaerobic energy production activate the enzyme—serotonin, tryptophan, cysteine, histamine, estrogen, aldosterone, HIF, SSRIs, angiotensin, and parathyroid hormone, for example."
- March 2020 - Ray Peat's Newsletter
0 upvotes"The endotoxin, lipopolysaccharide, has a general excitatory effect effect that activates cell inflammatory processes and damages energy production, with the mediation of cell products such as nitric oxide, carbon monoxide, serotonin, histamine, prostaglandins, estrogens, and various cytokines (interleukins and tumor necrosis factor,TNF). Some of these substances enter the blood stream from the intestine, others are produced elsewhere in the body, but some are produced in the brain itself, when endotoxin is absorbed into the brain"
- March 2017 - Ray Peat's Newsletter
0 upvotes"Histamine and serotonin and other inflammatory factors released by estrogen are known to contribute to its ability to produce edema. The excess nitric oxide produced under the influence of estrogen probably contributes to some edematous, inflammatory, and degenerative conditions."
- 2000 - January - Ray Peat's Newsletter
0 upvotes"Histamine release, nitric oxide, and carbon monoxide are broadly involved in excitotoxic damage, and carbon dioxide tends to be protective against these, too."
- 1999 - December- Ray Peat's Newsletter
0 upvotes"When a cell has been damaged (as by radiation or toxins), its inefficiency creates a small localized distortion im the fields, which will stimulate processes of repair or removal and replacement, as far as the organisms resources allow. When a stress is great enough that the entire organism is exposed to lactic acid, the organism’s adaptive resources are being challenged, and potentially harmful responses are evoked. For example, a sluggish liver can allow the blood lactate concentration to mse during stress, and this can lead to secretion of endorphins and pituitary hormones (Elias, et al, 1997). The endorphins can increase histamine release, and growth hornone increases free fatty acids; increased permeability of blood vessels can allow proteins and fats to leave the blood stream with cumulatively harmful effects."
- 1998 - Ray Peat's Newsletter - 2
0 upvotes"many of estrogen’s most important actions dont involve the receptors. A direct excitatory action on prostate cells, and indirect actions by way of the pituitary, pancreas, thyroid, adrenal, fatty acids, prostaglandins, histamine and circulation are probably essential parts of the cancenzation process."
- 1998 - May Ray Peat's Newsletter
0 upvotes"Calcium is a universal activator, but excess calcium is the central link in most types of cell damage. Calcium uptake and retention are promoted by adrenalin, histamine, vasopressin, energy depletion, and lipid peroxidation and by the activity of phospholipases; since calcium can activate phospholipases and lipid peroxidation, and interferes with energy production, vicious circles can develop."
- 1992 - June - Ray Peat's Newsletter
0 upvotes"A complete list of protective nutritional chemicals and natural drugs or analogs to our endogenous protective factors would be very long, but we should give special thought to certain ones, including succinic acid, which stimulates respiration and protective steroid synthesis; thyroid and vitamin E, which promote normal oxidation while preventing abnormal oxidation; magnesium; sodium and lithium, which help us to retain magnesium; tropical fruits, which contain GHB; coconut oil, which protects against cardiac necrosis, lipid peroxidation, hypothyroidism, hypoglycemia, and histamine damage; valium agonists, natural anti-histamines; adenosine and uridine. Visits to higher elevations, and exposure to bright, long-wave light, can cause the body to optimize its own antistress chemistry. Avoiding the sense of being trapped is a high-level adaptive factor."
- 1992 - June - Ray Peat's Newsletter
0 upvotes"When various kinds of cells are deprived of energy (mast cells are often studied) they tend to produce (and secrete) histamine (among other substances). Unsaturated fats promote the release of histamine, while short chain saturated fats, and glucose, inhibit it. W"
- 1991 - January - Ray Peat's Newsletter
0 upvotes"hen mice are killed by a variety of methods, they are found to have very high tissue histamine levels, so the high-histamine phenomenon seems to be about as generalized as shock."
- 1991 - January - Ray Peat's Newsletter
0 upvotes"Some inhibitory cells in the brain (including those involved in the coma state of protective inhibition) secrete acetylcholine. The similarity of the effects of histamine and acetylcholine are such that many people used to think of histamine as the systemic cholinergic hormone equivalent to acetylcholine. As a result of their similarity, any chemical which interferes with one of these transmitter substances is likely to interfere with the other, though not necessarily in the same way."
- 1991 - January - Ray Peat's Newsletter
0 upvotes"Estrogen-induced thyroid hypofunction can be compensated to some degree by various hormonal adjustments; elevated secretion of adrenalin and cortisol are common. When the compensation is inadequate, there will often be hypoglycemia and a tendency to form too much histamine. Too much adrenalin will cause cold hands and feet, too little will cause orthostatic hypotension (blacking out when you stand up too quickly) and bowel spasms,"
- 1990 - August.September - Ray Peat's Newsletter
0 upvotes"histamine tends to exacerbate hypoglycemia (e.g., by its acetylcholine-like actions) and it is directly immunosuppressivein many ways. It inhibits lymphocyte proliferation in Te response to stimulation, it inhibits antibody formation and lymphocytotoxicity, it suppresses cutaneous delayed hypersensitivity and release of lymphokines, and it suppresses both the generation of T-helper cells and their effector function"
- 1989 - November - Ray Peat's Newsletter
0 upvotes"Besides the ordinary antihistamines and receptor blockers, the release of histamine can be inhibited by manyother substances which areimmunoprotective, such as epsilon-aminocaproic acid, and by the saturated fatty acids, from pentanoic to dodecanaic."
- 1989 - November - Ray Peat's Newsletter
0 upvotes"Since tumors often contain very large quantities of mast cells, immune therapy for tumors should take histamine into account."
- 1989 - November - Ray Peat's Newsletter
0 upvotes