Ray Peat on hyperventilation

Hyperventilation, CO2 Loss, and Serotonin Release

"Hyperventilation tends to increase under various stresses, and the resulting loss of carbon dioxide increases the alkalinity of the blood, which causes the platelets to release serotonin. Estrogenic stimulation and hypothyroidism are common causes of chronic hyperventilation, with its effect on platelets, releasing serotonin, with all its harmful consequences."

- September 2019 - Ray Peat's Newsletter

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Hypothyroidism's Link to Chronic Stress and Metabolic Issues

"In hypothyroidism, with lowered oxidative metabolism, the organism is never far from stress and hyperventilation, with the chronic production of lactate and ammonia. The inefficient metabolism of diabetes has similar effects."

- July 2017 - Ray Peat's Newsletter

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Hypothyroidism, Stress, and Related Physiological Complications

"Hypothyroid people, with low production of CO2, are very susceptible to stress-induced hyperventilation, and they are often in a state of physiological hyperventilation. They are susceptible to over-production of ammonia (De Nardo, et al., 1999; Marti, et al., 1988) and lactate (Zarzeczny, et al., 1996), and to psychosis, especially depression and mania."

- July 2017 - Ray Peat's Newsletter

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Importance of Monitoring Ammonia and Lactate Levels

"Because of their role in producing and maintaining pseudohypoxia, and stimulating hyperventilation, there should be more attention to measuring the presence of ammonia and lactate in the blood, breath and urine."

- July 2017 - Ray Peat's Newsletter

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Hypothyroidism, Hyperventilation, and a Vicious Circle of Energy Loss

"Hypothyroidism suppresses respiration as a source of energy so little carbon dioxide is produced, and lactic acid is formed even when there is no noticeable stress. This in itself resembles hyperventilation, since loss of carbon dioxide is the defining feature of hyperventilation, but the presence of abnormally high adrenergic activity, and of free fatty acids, stimulates further hyperventilation, exacerbating the loss of carbon dioxide. Decreasing the carbon dioxide impairs respiration even more, leading to increased lactic acid production, and that stimulates more adrenergic activity, and so on, in a vicious circle."

- 2000 - January - Ray Peat's Newsletter

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CO2 Loss Impact on Brain Circulation and Hyperventilation Effects

"The loss of carbon dioxide reduces brain circulation, creating complex paresthesias and stroke symptoms. Hyperventilation is a relative term, and refers to the amount of carbon dioxide which is lost from the blood. Heavy, rapid breathing at high altitude or in the presence of a carbon dioxide-rich atmosphere, doesn’t necessarily constitute hyperventilation."

- 1999 - December- Ray Peat's Newsletter

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Hyperventilation Experiment: Muscle Spasms and Altered Blood pH

"Simple hyperventilation causes muscle spasms and paresthesia (prickling of the skin), in an experiment anyone can perform in a few minutes. When a large amount of carbon dioxide is blown off, the blood’s pH increases very slightly, because of systemic adjustments."

- 1999 - December- Ray Peat's Newsletter

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Hyperventilation's Role in Vascular Permeability and Hemoconcentration

"Hyperventilation causes increased vascular permeability, leading to hemoconcentration when a large portion of the blood’s water escapes into the tissues."

- 1999 - December- Ray Peat's Newsletter

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