Ray Peat on inflammation

"inflammation is seen to be intrinsic to the disease process itself, in an increasing number of the chronic and degenerative diseases—dementia, psychosis, atherosclerosis, osteoporosis, cancer, for example."

- September 2019 - Ray Peat's Newsletter

"When metabolic energy is failing, as in hypothyroidism, muscles become easily fatigued, and take up excess water, and the barrier structure is loosened, allowing macromolecules and ATP and other metabolites to leak out, while extraneous substances enter. Typical muscle enzymes such as lactate dehydrogenase and creatine kinase appear in the bloodstream in typical hypothyroid myopathy, and heart proteins, including a particular form of lactic dehydrogenase and a muscle protein, troponin, appear in the blood after a heart stress or fatigue combined with hypothyroidism or systemic inflammation."

- September 2019 - Ray Peat's Newsletter

"Stresses of different sorts increase the formation of serotonin and the various pituitary hormones, leading to adaptive changes in the organism, but at the cost of causing inflammation and degeneration. Studies of several of the pituitary hormones have shown age-accelerating effects, leading to edema, inflammation, fibrosis, and decreased longevity. W.D. Denckla’s experiments showing the great life extending effect of removing the pituitary gland, while supplementing thyroid and glucocorticoid hormones, suggest the possibilities inherent in finding ways to prevent the over-production of serotonin and its associated hormones and cytokines."

- September 2019 - Ray Peat's Newsletter

"The actual physical stiffness of whole cells and their surroundings is very important. For example excitotoxicity (Fang, et al., 2014), and other forms of energy depletion can stiffen cells, and prolonged energy depletion and inflammation lead to degenerative changes—tissue calcification, fibrosis, and invasive, disorganized cell movement, for example. These stress related stiffenings of the cell substance and matrix have nothing directly to do with the local quantity of cholesterol."

- September 2018 - Ray Peat's Newsletter

"The age pigment, ceroid or lipofuscin, that’s derived largely from PUFA and associated with the macrophage foam cells in the plaque, accumulates iron (Lee, et al, 1998), and by catalyzing oxidation, creates local hypoxia, leading to lactic acid production, contributing to an inflammatory process. The products of lipid peroxidation, such as azelaic acid (Riad, et al., 2018), along with lactate, lead to the calcification of tissue."

- September 2018 - Ray Peat's Newsletter

"Phosphate, which predominates in grains, beans, nuts, meats, and fish, increases our production of parathyroid hormone, while calcium and magnesium inhibit its production. This hormone, which increases with age, suppresses immunity, and in excess it causes insomnia, seizures, dementia, psychosis, cancer, heart disease, respiratory distress and pulmonary hypertension, osteoporosis, sarcopenia, histamine release, inflammation and soft tissue calcification, and many other problems."

- September 2017 - Ray Peat's Newsletter

"Any food that provides simple nutrients, without causing inflammation and blocking enzymes, will support the animal’s normal development, without activating stress responses."

- September 2017 - Ray Peat's Newsletter

"The reduction of parathyroid hormone by increased calcium and vitamin D is closely related to reduced obesity, and to the health problems associated with obesity—hypertension, insulin resistance, heart arrhythmias, depression, and various inflammatory conditions."

- September 2017 - Ray Peat's Newsletter

"But a large inflammation, or profound exhaustion, will lower the blood sugar systemically, and will deliver large amounts of lactic acid to the liver. The liver synthesizes glucose from the lactic acid, but at the expense of about 6 times more energy than is obtained from the inefficient metabolism — so that organismically, that tissue becomes 90 times less efficient than its original state. Besides this, an idle destruction of energy molecules (ATP or creatine phosphate) will increase the wastefulness even more."

- Nutrition For Women

"When the organism detects the inflammation or other stress (possibly by sensing changes in blood sugar, lactic acid, or carbon dioxide, or all of them) its adrenal glands will secrete anti-stress hormones, including adrenalin and cortisone (assuming these glands are not exhausted or starved). Both adrenalin and cortisone can raise blood sugar to meet the increased need."

- Nutrition For Women

"Selye classifies steroids into anti- and proinflammatory. Inflammation is a relatively non-specific, and hopefully local, reaction, serving to isolate the problem if it is a toxin or infection. Cortisol is a typical antiinflammatory hormone;"

- Nutrition For Women

"Cancer patients are typically unable to even produce a normal inflammation, as if they are powerfully dosed with the anti-stress cortisone-type hormones. The failure of the immune system, which can normally wipe out cancer cells as they develop, seems to be an essential feature of cancer"

- Nutrition For Women

"Copper is a specific oxidant for vitamin C. It is associated with many inflammatory diseases, and should probably be better investigated in degenerative diseases, including arthritis and glaucoma."

- Nutrition For Women

"Sensory nerves can release ATP into surrounding tissues, and this seems to be part of their trophic influence on healing and inflammation. A.E. Needham (Growth Process of Animals) has discussed the possibility that it is a vitamin: when added to the diet of animals, it increases their growth. This must have some relevance to our nutrition, since fresh food contains abundant ATP."

- Nutrition For Women

"The reaction against Broda Barnes’ use of temperature to diagnose hypothyroidism was partly motivated by the belief that a subnormal temperature is protective. This deep belief has probably contributed to the official preference for use of the relatively inactive thyroxin rather than the thermogenically active thyroid, USP, and T3, and to the lack of interest in the association between hypothermia and chronic infections, heart and circulatory problems, kidney disease, chronic inflammatory disease and other problems that increase with aging."

- November 2020 - Ray Peat's Newsletter

"The higher rate of oxygen consumption that occurs at higher body temperature corresponds to a high rate of carbon dioxide production, and an inhibition of lactate formation, with maintenance of a more oxidized balance that reduces inflammation."

- November 2020 - Ray Peat's Newsletter

"In one study (Alhazmi, et al., 2018), T3 was four and a half times higher in people living at a high altitude, T4 was about three times higher, and TSH (a promoter of inflammation) was reduced by more than 25%. The high altitude studies show very convincingly that a high metabolic rate is strongly associated with greater longevity and better health."

- November 2020 - Ray Peat's Newsletter

"Starting suddenly around the time of menopause, cortisol is higher, probably as compensation for the lost stabilizing effects of progesterone, and the increased inflammatory processes resulting from lower body temperature."

- November 2020 - Ray Peat's Newsletter

"Aromatase, the enzyme that produces estrogen, is present in muscles, fat, blood vessels, and many other tissues, and its activity is increased by cortisol, and decreased by progesterone. The changed activity of these two steroids at menopause can account for the sudden increase in the degenerative diseases, inflammation, depression, etc."

- November 2020 - Ray Peat's Newsletter

"Respiratory and circulatory problems increase with menopause, corresponding to increases in inflammatory cytokines and cortisol, and decreases in progesterone and thyroid hormone. Both thyroid and progesterone are thermogenic, and lower estrogen levels."

- November 2020 - Ray Peat's Newsletter

"Things that decrease energy and body temperature increase some essential mediators of inflammation, and those changes are deeply associated with the processes of aging."

- November 2020 - Ray Peat's Newsletter

"Inflammation is a kind of adaptive response, but it leaves behind some fibrotic changes and atrophy of functional cells, along with an increased tendency to resort to the inflammatory response."

- November 2020 - Ray Peat's Newsletter

"If longevity is shortened as a result of the accumulation of changes resulting from inflammatory adaptations, then living in different environments, requiring different kinds of adaptation, will cause major changes in lifespan."

- November 2020 - Ray Peat's Newsletter

"Altitude and a milk based diet are obviously two important thermogenic factors that slow the accumulation of harmful adaptations, but there are many other controllable factors that could extend longevity even more. Reducing inflammatory factors is important, and personal choices can make a big difference, for example choosing easily digestible foods to reduce endotoxin, avoiding the polyunsaturated fatty acids that interfere with cell respiration and form inflammatory prostaglandins, avoiding antioxidant supplements that create a reductive excess, and choosing foods that contain antiinflammatory-thermogenic compounds, such as citrus fruits with their high content of flavonoids that support cell respiratory functions."

- November 2020 - Ray Peat's Newsletter

"Part of the basic cellular defense reaction involves enzymes that process toxins in ways that improve the immediate situation, but that can create new problems for the organism if they become chronic. For example, stressed tissues produce carbon monoxide and estrogen, which prevent apoptosis and promote autophagy, with short-term survival value. Surviving in the stressed condition under the influence of CO and estrogen, the cells produce cytokines that affect the sensitivity of surrounding cells to stress and inflammation, and progressively undergo epigenetic changes, tending to become cells of a different type,"

- November 2017 - Ray Peat's Newsletter

"the proper function of heme oxygenase is to support progressive improvement in the organism’s phenotype, rather than the aging, inflammation, fibrosis, and cancer, that are now the eventual result of its activity. Heme oxygenase, and enzymes that make NO, HCN, and H2S, might simply need the guidance of an organism’s response to an enriched environment."

- November 2017 - Ray Peat's Newsletter

"In the early embryo, where there are no pathogens, TNF and interferon are present, acting as regulators of cell development and differentiation (Li, et al., 2014). Estrogen participates in the embryonic definition of the dorso-ventral polarity (Carroll, et al.,, 2014). In the absence of pathogens, these signals of inflammation are morphogens, links in the organismic field."

- November 2016 - Ray Peat's Newsletter

"When the organism is injured, the system’s morphogens are called into action; if no foreign organism is responsible for the injury, the reaction is called sterile inflammation. In a healthy young organism, the repairs are made to restore the field’s integrity,"

- November 2016 - Ray Peat's Newsletter

"if the organism lacks the necessary resources of substance and energy, the distortion of the field persists, potentially aggravating the deficiencies, leading to a state of chronic inflammation and degeneration. When there is no injury, the same signals guide the continuing processes of renewal."

- November 2016 - Ray Peat's Newsletter

"he field, the organism’s integrity, is sustained by organized respiratory metabolism, and it can be interrupted by mechanical trauma, excessive stimulation, poisons, etc., or by the absence of oxygen, of glucose, or of substances that specifically neutralize the inflammatory signals."

- November 2016 - Ray Peat's Newsletter

"The estrogenprogesterone polarity of pregnancy exists in the adult tissues, as the polarity of growth and maturation, of inflammation and normalization."

- November 2016 - Ray Peat's Newsletter

"Almost as soon as purified estrogen was available for research in the 1930s its ability to produce inflammation, cancer, miscarriages, and convulsions was recognized,"

- November 2016 - Ray Peat's Newsletter

"Endotoxin absorbed from the intestine during stress promotes many inflammatory reactions, and activates aromatase"

- November 2016 - Ray Peat's Newsletter

"Because of the inefficient use of glucose in hypothyroidism, fatty acids are mobilized from the tissues, and these contribute to stress and inflammation. In the autoimmune diseases, free fatty acids are consistently high."

- November 2016 - Ray Peat's Newsletter

"the free fatty acids promote the effects of estrogen, and increase the formation of the inflammatory prostaglandins, which activate aromatase. Since estrogen increases lipolysis and elevates free fatty acids, and promotes their conversion to prostaglandins, this process initiated by stress easily becomes a selfsustaining vicious circle."

- November 2016 - Ray Peat's Newsletter

"The reduced inflammation can permit some restorative processes to work, but the drugs aren’t curative. A more biological approach would be to reduce exposure to the factors that damage the thymus or over-excite the B cells."

- November 2016 - Ray Peat's Newsletter

"DMSO apparently introduces somehydrophobicity into water, because of its strong hydrogen bonding oxygen and its methyl groups--at least it seems to lower the effective activity of water (Berezin, Ugarova, and Silaev, 1973). This may mimic the resting state of protoplasm to some extent, since it seems to improve metabolic efficiency: Reducing inflammation and treating mental retardation are its best known (apparent) effects."

- Mind And Tissue Russian Research Perspectives on the Human Brain

"Unresolved excitation causes cells to emit signals indicating the need for repair, inflammatory signals."

- May 2020 - Ray Peat's Newsletter

"Pre-existing inflammation is associated with high altitude sickness and the ability to get sick from a corona virus, as well as chronic diseases."

- May 2020 - Ray Peat's Newsletter

"treatment for a so-called coronavirus infection should be to reduce cellular excitation and inflammation and normalize energy production. It also implies that these treatments will have favorable effects on cell aging."

- May 2020 - Ray Peat's Newsletter

"The conditions that produce inflammation activate the adaptive exosome system, a retrotransposon system involving a massive block of our DNA, which overlaps with the virus production mechanism."

- May 2020 - Ray Peat's Newsletter

"Cumulative injury of all sorts contribute to a background of inappropriate excitation and inflammation."

- May 2020 - Ray Peat's Newsletter

"In a state of chronic stress, oxidative energy production is low, and mediators of inflammation are likely to be chronically increased; there is typically a chronically increased production of lactate, and/or decreased oxidation of it. I"

- May 2020 - Ray Peat's Newsletter

"Reduction by stress and/or lactate activates the channels, tightening vascular smooth muscle, and activating a wide range of other cell activities, including inflammation, exosome secretion,"

- May 2020 - Ray Peat's Newsletter

"Nitric oxide is a powerful oxidant that can destroy viruses, and it happens to dilate blood vessels. Doctors have almost unanimously recommended it to treat the corona virus infection; however, it is associated with inflammation (Weidinger, et al., 2015), and promotes fibrosis, and fibrosis is a sequela of coronavirus disease."

- May 2020 - Ray Peat's Newsletter

"a barely recognizable background of inflammation predisposes to develop serious sickness from a corona virus,"

- May 2020 - Ray Peat's Newsletter

"The pharmaceutical myth about serotonin, the happy hormone, has led most people, even researchers, to ignore the fact that it increases inflammation and activates the stress system, while reducing the efficiency of energy production."

- May 2019 - Ray Peat's Newsletter

"Drug company manipulation of information about estrogen has been more extreme than its treatment of serotonin. Activated by stress, along with serotonin, it is one of the major activators of the corticotropin release hormone, CRH, which activates the pituitary and adrenal glands, and promotes inflammation, and is a major factor in PPD (Glynn and Sandman, 29014, HahnHolbrook, 2016), as well as in other types of depression, and aging, and Alzheimer’s disease."

- May 2019 - Ray Peat's Newsletter

"In the tissues of the cancer field, inflammation and fibrosis are processes that precede and accompany carcinogenesis, so all of the knowledge that relates to the development and resolution of inflammation and fibrosis is relevant to understanding and controlling cancer."

- May 2016 - Ray Peat's Newsletter

"The doctrine that inflammation is a necessary part of immunity, leading to destruction of the pathogen, affects the way diseases are treated."

- March 2021 - Ray Peat's Newsletter

"Poor nutrition, aging, and other stresses weaken our antiinflammatory defenses, leading to chronic systemic inflammation,"

- March 2021 - Ray Peat's Newsletter

"Biologists usually say that any trait found in an organism is the result of natural selection, and the presumption is that it has been beneficial at some time in our history. This presumption tends to support the complex stories that textbooks tell about the role of inflammation in disease and immunity."

- March 2021 - Ray Peat's Newsletter

"A failure of energy, caused by hypoglycemia or interference with the use of oxygen, stops the formative developmental processes, and the constructive actions of the cytokines can become destructive, causing inflammation, probably accounting for a large portion of birth defects"

- March 2021 - Ray Peat's Newsletter

"Prolonged exposure to environmental conditions that are far from the perfect conditions of healthy gestation results in a systemic inflammatory state, and this chronic inflammation leads to the degenerative processes of aging, with a failure of the tissue restorative processes."

- March 2021 - Ray Peat's Newsletter

"It’s the oxidation of glucose (producing carbon dioxide), which is favored by warmth and the right amount of insulin, that can prevent inflammation"

- March 2021 - Ray Peat's Newsletter

"Inflammation is involved in the chronic degenerative conditions, especially atrophy and cancer, and even in depression"

- March 2019 - Ray Peat's Newsletter

"Interference with energy production is fundamental to inflammation. When cellular stimulation increases faster than oxygen can be delivered, there is a shift to glycolytic energy production, with the conversion of glucose and amino acids to lactic acid."

- March 2019 - Ray Peat's Newsletter

"Small particles of silica or other inorganic or organic material (such as plastics), can, like radiation, oxygen deprivation, sepsis, or estrogen, increase the production of lactic acid, and this lactate promotes various features of inflammation, including edema, collagen synthesis, and the growth and movement of cells."

- March 2019 - Ray Peat's Newsletter

"Our so-called immune system detects unfavorable changes in the structural-energetic system, and reacts quietly to restore the system, removing abnormal structures, and facilitating the restoration of function. When the organism’s situation isn’t good, instead of invisible restoration there is inflammation, a process in which crude provisional repairs are made, so that the damaged tissue doesn’t continue to demand resources that aren’t available. A scar is formed, a relatively inert fibrotic tissue replaces the fully functional tissue. This happens progressively with continued exposure to harmful factors, degrading the lungs, heart, blood vessels, gonads, liver, kidneys, brain ...."

- March 2019 - Ray Peat's Newsletter

"The process of inflaimmation and fibrosis is initiated in response to anything that blocks the adequate production of energy. Very different factors can have additive or synergistic effects leading to the same conditions of inflammation and fibrosis."

- March 2019 - Ray Peat's Newsletter

"Ionizing radiation, particulate matter, and estrogen excess interfere with the system in different ways, but all produce reductive stress, inflammation, collagen synthesis, and loss of differentiated cellular functions."

- March 2019 - Ray Peat's Newsletter

"When cells are excited, they release some ATP into their local surroundings, where it signals fatigue or injury, activating the formation of inflammatory factors such as TNF-alpha, which promote the sleep rhythm."

- March 2018 - Ray Peat's Newsletter

"The intensity of lipolysis during the night is decreased during the most restorative deep sleep, but the free fatty acids themselves, by blocking oxidation of glucose to carbon dioxide, tend to increase lactate and to depress glucose metabolism, creating an inflammatory and excitatory state that interferes with deep sleep."

- March 2018 - Ray Peat's Newsletter

"The endotoxin, lipopolysaccharide, has a general excitatory effect effect that activates cell inflammatory processes and damages energy production, with the mediation of cell products such as nitric oxide, carbon monoxide, serotonin, histamine, prostaglandins, estrogens, and various cytokines (interleukins and tumor necrosis factor,TNF). Some of these substances enter the blood stream from the intestine, others are produced elsewhere in the body, but some are produced in the brain itself, when endotoxin is absorbed into the brain"

- March 2017 - Ray Peat's Newsletter

"Men’s testosterone declines with stress and aging, and its conversion to estrogen is increased by stress and inflammation. Endotoxin specifically increases the conversion of testosterone to estrogen"

- March 2017 - Ray Peat's Newsletter

"Despite its toxicity, L-DOPA continues to be the main medical treatment for Parkinson’s disease, though the more appropriate drugs bromocriptine, amantadine, and memantine are also widely used. Anticholinergics, similar to the hyoscyamine and belladonna that Charcot used, are sometimes used to control excessive salivation. Amantadine and memantine happen to protect against nitric oxide, serotonin, inflammation, and endotoxin, and to protect mitochondria."

- March 2017 - Ray Peat's Newsletter

"Treatment with dihydrotestosterone (which can’t be converted to estrogen) might be more effective than with ordinary testosterone, considering the increased activity of aromatase with age, stress, and inflammation, and the probable role of estrogen in the excitatory degenerative process."

- March 2017 - Ray Peat's Newsletter

"The inflammatory, degenerative processes in the brain take a few hours to develop, and during these few hours the stress signals from the brain are causing changes in the intestine that lead to a systemic inflammatory state"

- March 2016 - Ray Peat's Newsletter

"Giving progesterone orally would seem to be appropriate for any serious stress, since the intestine quickly becomes an amplifier of the inflammatory reactions."

- March 2016 - Ray Peat's Newsletter

"free fatty acids, especially when they are polyunsaturated, are toxic to the brain, increasing inflammation and blocking energy metabolism."

- March 2016 - Ray Peat's Newsletter

"Several of these substances inhibit the liberation of free fatty acids and prostaglandin formation, and reduce nitric oxide, lactate production, inflammation, excitation and cholinergic tone, and what they all have in common is supporting a shift away from a highly reduced condition, a shift toward an oxidized-energized balance."

- March 2016 - Ray Peat's Newsletter

"Although its name, serotonin, is based on the fact that it constricts blood vessels, it also increases their leakiness. Both of these actions contribute to its role in fatigue and inflammation, and to the therapeutic effects of serotonin antagonists in a variety of problems including arthritis (Cloutier, et al.,, 2012) and traumatic brain injury"

- July 2019 - Ray Peat's Newsletter

"The ideology around stress physiology, falsifying the meaning of serotonin, estrogen, unsaturated fats, sugar, lactate, carbon dioxide, and various other biological molecules, has hidden the simple remedies for most of the inflammatory and degenerative diseases."

- July 2019 - Ray Peat's Newsletter

"Avoiding prolonged fasting and stressful exercise that increase free fatty acids, and combining sugars with proteins to keep free fatty acids low, and using aspirin, niacinamide, or cyproheptadine to reduce the formation of free fatty acids by unavoidable stress, avoiding an excess of phosphate relative to calcium in the diet, having milk and other antistress foods at bedtime or during the night, and being in a brightly lighted environment during the day, with regular sunlight exposure, can minimize the harmful effects of excessive serotonin and reduce the inflammation, fibrosis, and atrophy associated with it."

- July 2019 - Ray Peat's Newsletter

"The estrogen so-called receptor can act, without the presence of estrogen, when the cell is stressed by hypoxia, ionizing radiation, or inflammation, allowing things that damage the cell to supplement whatever estrogen is present."

- July 2018 - Ray Peat's Newsletter

"These shifts toward pseudohypoxia, alkalinity, excitation, water retention, and inefficient energy production can be seen, either locally or systemically, in all of the chronic and degenerative conditions that are now known to involve inflammation."

- July 2017 - Ray Peat's Newsletter

"Direct use of carbon dioxide is likely to be helpful in all the situations that are known to be benefitted by acetazolamide, without the risk of allergy to that drug—traumatic brain edema, mountain sickness, osteoporosis, epilepsy, glaucoma, hyperactivity (ADHD), inflammation, polyps of the intestine, and arthritis. Diabetes, cardiomyopathy (Torella, et al., 2014), obesity (Arechederra, et al., 2013), cancer, dementia and psychosis are also likely to benefit."

- July 2017 - Ray Peat's Newsletter

"In the first reactions to injury, the inflammatory changes activate enzymes that support undifferentiated growth."

- July 2016 - Ray Peat's Newsletter

"Cellular starvation, beginning with the tumor focus of metabolic inefficiency, increases inflammation, shifting the fuel metabolism, creating pseudohypoxia, in a vicious progression."

- July 2016 - Ray Peat's Newsletter

"In severe prolonged stress, the body’s stresslimiting parasympathetic nervous system can become counter-productive, promoting excitotoxicity, inflammation, and tumor growth."

- July 2016 - Ray Peat's Newsletter

"Metchnikoff recognized that phagocytes in parts of the body remote from the inflammatory stimulus were attracted to the damaged area, and he investigated their role in tissue repair and the development of the embryo."

- January 2020 - Ray Peat's Newsletter

"Up until the beginning of this century, inflammation had usually been thought of as a simply constructive part of the local healing process, but it was starting to be recognized to have a universal role in pathology. Tissue injury was no longer seen as a merely local event. Research was being forced toward a reconsideration of Metchnikoff’s holistic, developmental view of immunity. Bystander effects, the emission by any injured cell of substances that induce a similar injury in other cells, even in remote parts of the body (Koturbash, 2007; Kovalchuk, 2016), and the persistent epigenetic changes they involve, are part of innate immunity. This system is activated by adjuvants, as well as the adaptive immune system that produces antibodies."

- January 2020 - Ray Peat's Newsletter

"From the 1930s to the 1950s, the steroid hormones and their physiological effects were being studied in objective biophysical ways, at the same time that they were being converted into products by the pharmaceutical cartels. Their general properties, including anesthesia, inflammation, and carcinogenesis, were considered in terms of universal, general properties of cells and tissues."

- January 2019 - Ray Peat's Newsletter

"While hypothyroidism makes the body require more cortisone to sustain blood sugar and energy production, it also limits the ability to produce cortisone, so in some cases stress produces symptoms resulting from a deficiency of cortisone, including various forms of arthritis and more generalized types of chronic inflammation."

- Generative Energy Restoring The Wholeness Of Life

"Increased cortisol is a normal response to the cell-damaging effects of stress or inflammation, but cortisol itself causes the death of nerve cells and immune cells through excitotoxicity, by blocking glucose metabolism. Estrogen increases cortisol production in a variety of ways, acting both through the pituitary and directly on the adrenal glands."

- 2001 - February

"Increased adrenaline, like increased cortisol, is a feature of depression, stress, and inflammation; mobilizing fats, it can become part of a vicious circle, in which free fatty acids cause insulin resistance, activating the stress reactions."

- 2001 - February

"Histamine and serotonin and other inflammatory factors released by estrogen are known to contribute to its ability to produce edema. The excess nitric oxide produced under the influence of estrogen probably contributes to some edematous, inflammatory, and degenerative conditions."

- 2000 - January - Ray Peat's Newsletter

"Both Alzheimer’s disease and multiple sclerosis involve depressed brain metabolism combined with an inflammatory process."

- 1999 - December- Ray Peat's Newsletter

"Shock, inflammation, aging and death have been proposed to have survival value, because of this totalitarian view of genetics. Couldnt it be that organisms simply arent perfect, and that some things are just systematically screwed up? That ts, an organism has a certain strength, resistance, or adaptive capacity, but if it finds itself in conditions that are too difficult, then processes that never did anything to aid survival might develop, as several individually valid defensive maneuvers ‘start to interfere with each other."

- 1998 - Ray Peat's Newsletter - 4

"What we call inflammation offers a good conceptual link between the studies on excitotoxicity or cellular stress, and the newer approaches to the treatment of aging and degenerative diseases, based on ideas of regeneration and development. Controlling inflammation becomes part -of promoting regeneration."

- 1998 - Ray Peat's Newsletter - 2

"Injury potential and inflammation are closely related; for example, I found that sunburned skin, or skin irritated by the application of a prostaglandin, had a negative polarity relative to normal adjacent skin."

- 1998 - Ray Peat's Newsletter - 2

"Hypertonic sodium chloride (Clifford White, Lancet, October 80, 1915) was also used to trest infected wounds, and its success in treating war wounds led to its use as a vaginal douche in treating various inflammations and infections, including infections associated with child-birth, salpingitis, cellulitis, gonorrhes, vaginitis, anderosions of the cervix, and in preparing a cancerous cervix for surgery."

- 1991 - July - Ray Peat's Newsletter