Ray Peat on niacinamide

Estrogen's Effect on Tryptophan Metabolism

"Estrogen strongly affects the metabolism of tryptophan, increasing its conversion to serotonin at the expense of niacinamide, which accounts for the symptoms of pellagra when the diet lacks tryptophan. When there’s enough protein in the diet, promotion of serotonin synthesis won’t result in a niacinamide deficiency, but conditions that increase the influence of estrogen will also increase the malfunctions involving serotonin."

- September 2019 - Ray Peat's Newsletter


Nutritional Therapy and Hormonal Support for Abnormal Pap Smears

"Many women with abnormal Pap smears, even with a biopsy showing the so-called carcinoma in situ, have returned to normal in just two months with a diet including the following: 90 grams of protein, 500 mg. of magnesium as the chloride, 100,000 units of vitamin A, 400 units of vitamin E, 5 mg. of folic acid, 100 mg. of pantothenic acid, 100 mg. of B6, 100 mg. of niacinamide, and 500 mg. of vitamin C, with thyroid and progesterone as needed. Liver should be eaten twice a week. Some of the women apply vitamin A directly to the cervix."

- Nutrition For Women


Protective Factors in Parkinson’s Broadly Counteract Estrogen

"things that are likely to be protective in Parkinson’s disease are broadly protective against estrogen and the inflammatorydegenerative processes: Progesterone, minocycline and other anti-inflammatory antibiotics, agmatine, aspirin, coffee, niacinamide, citrus flavonoids, vitamin D, ACE inhibitors, fibrous-antiseptic foods."

- March 2017 - Ray Peat's Newsletter


List of Various Medications and Supplements

"Acetazolamide, agmatine, amantadine, aminoguanidine, antibiotics (minocycline, tetracycline, etc.), antihistamines, aspirin, bromocriptine, DCA, emodin, glucagon, glucose, memantine, methylene blue, niacinamide, T3 (triiodothyroinne), vitamin D, vitamin E."

- March 2016 - Ray Peat's Newsletter


Mitigating Excessive Serotonin's Harmful Effects

"Avoiding prolonged fasting and stressful exercise that increase free fatty acids, and combining sugars with proteins to keep free fatty acids low, and using aspirin, niacinamide, or cyproheptadine to reduce the formation of free fatty acids by unavoidable stress, avoiding an excess of phosphate relative to calcium in the diet, having milk and other antistress foods at bedtime or during the night, and being in a brightly lighted environment during the day, with regular sunlight exposure, can minimize the harmful effects of excessive serotonin and reduce the inflammation, fibrosis, and atrophy associated with it."

- July 2019 - Ray Peat's Newsletter


Protective Substances Against Impaired Glucose Oxidation Effects

"Other substances that protect against the effects of hypoglycemia or impaired glucose oxidation include progesterone, caffeine, certain anesthetics including xenon, niacinamide, agmatine, carbon dioxide,"

- January 2017 - Ray Peat's Newsletter


Defense Mechanisms Against Nitric Oxide: The Nutritional Angle

"Some of the most important anti-nitric oxide defenses are progesterone, vitamin E, vitamin K, vitamin A, niacinamide, coffee, aspirin, and foods containing flavonoids, terpenoids, polyphenols, and sterols. Grass-fed milk contains a variety of polyphenols. Citrus fruits, many tropical fruits (e.g., guavas, longans, and lychees), and cooked mushrooms are good sources of apigenin, naringenin and related chemicals."

- January 2016 - Ray Peat's Newsletter