Ray Peat on parathyroid hormone
"Phosphate, which predominates in grains, beans, nuts, meats, and fish, increases our production of parathyroid hormone, while calcium and magnesium inhibit its production. This hormone, which increases with age, suppresses immunity, and in excess it causes insomnia, seizures, dementia, psychosis, cancer, heart disease, respiratory distress and pulmonary hypertension, osteoporosis, sarcopenia, histamine release, inflammation and soft tissue calcification, and many other problems."
- September 2017 - Ray Peat's Newsletter
0 upvotes"Drinking milk lowers parathyroid hormone, relative to the diets that chronically stimulate its production. There has been very little attention given to the optimal level of parathyroid hormone, as opposed to the normal range."
- September 2017 - Ray Peat's Newsletter
0 upvotes"When vitamin D or calcium is deficient, or when phosphate is excessive, and in hypoglycemia and stress (Ljunghall, et al., 1984), parathyroid hormone increases. This can lead to softening of bones, and hardening of soft tissues, especially arteries, sometimes brain, skin and other organs. Parathyroid hormone increases blood pressure, even before the calcium stiffening is detected."
- September 2017 - Ray Peat's Newsletter
0 upvotes"During the night, parathyroid hormone usually rises (Radjaipour 1986; Logue 1989, 1990; Fraser, 1998), and especially during aging, this causes a significant loss of calcium from the bones. Having a large part of the day’s calcium at bedtime reduces the nocturnal rise of PTH and calcium loss from bones"
- September 2017 - Ray Peat's Newsletter
0 upvotes"The reduction of parathyroid hormone by increased calcium and vitamin D is closely related to reduced obesity, and to the health problems associated with obesity—hypertension, insulin resistance, heart arrhythmias, depression, and various inflammatory conditions."
- September 2017 - Ray Peat's Newsletter
0 upvotes"In vitro experiments with hair follicles show that parathyroid hormone ends the growth cycle. Prostaglandin D2, associated with hair loss, is released from mast cells, and parathyroid hormone is an activator of mast cell degranulation. Hair growth has a 24 hour cycle, and the long cycle of hair shedding and renewal seems to be regulated by the genes involved in the daily cycle (Lin, et al., 2009). It’s possible that the daily cycle of parathyroid hormone is responsible for progressive hair loss,"
- September 2017 - Ray Peat's Newsletter
0 upvotes"Studies of progesterone’s effects on recovery of nerve function after traumatic brain damage have found that vitamin D increases its effectiveness. By improving calcium homeostasis, opposing the effects of the parathyroid hormone which activates calcium channels, vitamin D (25-hydroxycholecalciferol) is coming to be considered a neurosteroid (Groves, et al., 2014; Gezen-Ak and Dursun, 2019), as well as an essential factor in immunity"
- May 2020 - Ray Peat's Newsletter
0 upvotes"The levels of aldosterone and parathyroid hormone are increased by stress, with serotonin acting on the adrenal cortex and the parathyroid gland to increase their secretion. All three of those hormones act on the mitochondria to lower oxidative energy production."
- May 2019 - Ray Peat's Newsletter
0 upvotes"Increasing the amount of sodium and calcium (and vitamin D, which also helps to lower parathyroid hormone and aldosterone) in the diet can lower the secretion of aldosterone and parathyroid hormone, with a resulting increasing in oxidative energy production."
- May 2019 - Ray Peat's Newsletter
0 upvotes"the most important factors that can be optimized with existing resources. Healthier pregnancies will result in healthier and happier postpartum life. Some of these factors would be sunlight, vitamin D, milk, cheese, eggs, fruits and well cooked vegetables, fibrous foods, and optimizing thyroid function and pregnenolone and progesterone (which support mitochondrial function, protecting against aldosterone, parathyroid hormone, excess serotonin, CRK, and cortisol, besides increasing allopregnanolone), and using the safest antiinflammatory and antiserotonin drugs, such as aspirin and cyproheptadine, when they are needed."
- May 2019 - Ray Peat's Newsletter
0 upvotes"The oxidative processes that support purposive, creative functioning of the organism, optimize CO2 by inhibiting carbonic anhydrase; this enzyme is inhibited by thyroid hormone T3, progesterone, urea, caffeine, antipsychotic drugs, and aspirin. Agents that tend to cause reversion to the primitive anaerobic energy production activate the enzyme—serotonin, tryptophan, cysteine, histamine, estrogen, aldosterone, HIF, SSRIs, angiotensin, and parathyroid hormone, for example."
- March 2020 - Ray Peat's Newsletter
0 upvotes"Using snacks to minimize the nocturnal increase of free fatty acids and hypoglycemia is an effective way to support restorative sleep, and to retard the brain-aging effects of the accumulation of the unstable fatty acids. Calcium and vitamin D, sufficient to keep parathyroid hormone low, contribute to that process."
- March 2018 - Ray Peat's Newsletter
0 upvotes"About 88 years ago, W. K. Koch (who is known for his cancer therapy) studied the parathyroid hormone and its relation to tetany (prolonged muscle contraction) and convulsions, and was able to demonstrate that the major minerals, sodium, potassium, magnesium, and calcium are to some extent interchangeable in alleviating the tetany and convulsions produced by removal of the parathyroid gland, though magnesium was the most effective."
- 1999 - December- Ray Peat's Newsletter
0 upvotes"Water, proteins, oxygen, and minerals, are all crucially regulated by carbon dioxide. The enzyme, Garbonic anhydrase, which is regulated by hormones (including the parathyroid hormone) and nerves, accelerates the interchange between carbon dioxide and bicarbonate, each of which has special functions. Bicarbonate is more soluble in water, but carbon dioxide is more soluble in living substance and fats."
- 1999 - December- Ray Peat's Newsletter
0 upvotes