Ray Peat on prolactin
"Estrogen increases the formation of serotonin, and both of these substances increase the formation of prolactin, and activate the renin-angiotensin system, and increase secretion of the antidiuretic hormone vasopressin, all of which synergize with estrogen in promoting water retention. Serotonin increases the formation of estrogen, so a vicious circle can easily develop when the organism is under stress."
- September 2019 - Ray Peat's Newsletter
0 upvotes"Serotonin, along with estrogen, is the major promoter of prolactin secretion, and it also promotes TSH, ACTH, FSH, LH, GH, MSH, POMC, vasopressin, and oxytocin--all the pituitary hormones."
- September 2019 - Ray Peat's Newsletter
0 upvotes"Estrogen promotes production of prolactin, a protein hormone, and its close analog, growth hormone. Ionizing radiation, aging, and oxygen deprivation all cause biochemical changes similar to those produced by estrogen."
- Nutrition For Women
0 upvotes"Anything which produces tissue atrophy will tend to produce cancer. The important question is, what will induce differentiation and useful function in cancer cells? There are many substances which promote differentiation and oppose the effects of estrogen, and some of these have been found to be useful in cancer therapy. Among the substances opposing estrogen are dopamine and nickel, prolactin inhibitors; chalones, the tissue specific proteins which inhibit cell division (and possibly more ephemerally, the peptides of memory); the aprotic solvents, DMF and possibly DMSO; progesterone and testosterone; thyroxin and iodine; magnesium ATP, the stable form of the biological energy molecule; vitamin A, a protein-sparing nutrient which promotes differentiation, and vitamin E (and the closely related coenzyme Q, or ubiquinone)."
- Nutrition For Women
0 upvotes"The dopamineserotonin antagonism (e.g., in the control of prolactin secretion) can be modified by progesterone, thyroid, and other factors."
- Nutrition For Women
0 upvotes"During LSD research, it was noticed that people with chronic headaches, asthma, or psoriasis sometimes recovered completely during treatment with frequent doses of LSD. Another alkaloid derived from ergot, bromocriptine, is now being used to suppress lactation (such as is caused by prolactin-secreting pituitary tumor which develops after using oral contraceptives) and is used experimentally to treat Parkinsons disease. Both LSD and bromocriptine shift the ratio of two brain chemicals, DOPA and serotonin, towards DOPA dominance. Among the effects of this is an inhibition of prolactin secretion. Prolactin excess is involved in breast cancer and in other cell proliferation, probably including the rapid cell division in psoriasis."
- Nutrition For Women
0 upvotes"All of the effects of prolactin excess (including amenorrhea) which respond to an increase of the DOPA/ serotonin ratio can be obtained to some extent by other, more easily available, materials. Vitamin B6 , thyroid, and progesterone all have this action"
- Nutrition For Women
0 upvotes"Since tryptophan promotes formation of serotonin which stimulates release of prolactin, and prolactin activates the formation of sebum (oil) by the skin, large amounts of milk could promote a tendency toward acne, when there is a deficiency of B6, thyroid, progesterone, etc."
- Nutrition For Women
0 upvotes"W. Donner Denckla suggested that there is a death hormone in the pituitary gland, which appears at puberty and initiates the process of aging by suppressing the use of oxygen. He maintained that merely providing thyroid supplement wouldnt protect against it, and that it was a distinct hormone, although it tended to appear in tissue extracts in association with prolactin and growth hormone. Although I think there is still a lot to be learned about the pituitary hormones, I dont think Denckla discovered anything except puberty."
- Generative Energy Restoring The Wholeness Of Life
0 upvotes"Estrogen and prolactin do many things to interfere with respiration."
- Generative Energy Restoring The Wholeness Of Life
0 upvotes"The pituitary hormones have diverse functons, including effects on epithelial tissues, other than their classical functions. Growth hormone, ACTH (Lostroh and Li, 1957), and ACTH with prolactin (Tullner, 1963) stimulate prostate growth. Prolactin--which is increased by estrogen--stimulates growth of the rats lateral prostate (Holland and Lee, 1980), and stimulates the growth of human prostate epithelial cells in vitro (Syms, et al., 1985)."
- 1998 - May Ray Peat's Newsletter
0 upvotes"LH (luteinizing hormone) increases when progesterone or testosterone is deficient, and growth hormone and prolactin (which are closely associated in evolution) both increase under a variety of stressful situations, and with estrogenic stimulation."
- 1998 - May Ray Peat's Newsletter
0 upvotes"Prostate cancer patients who had higher levels of LH and lower testosterone died most quickly. (Harper, et al., 1984.) Also, a high ratio of testosterone to estradiol or of testosterone to prolactin corresponded to better survival (Rannikko, et al, 1981.) Considered separately, patients with higher testosterone levels had a better prognosis than those with lower levels, and patients with lower growth hormone levels did better than those with higher growth hormone levels. (Wilson, et al., 1985.)"
- 1998 - May Ray Peat's Newsletter
0 upvotes"In human prostate slices, several hormones —~ (including insulin, and probably prolactin) stimulated cell division; testosterone did mot,, under these experimental conditions. (McKeehan, et al., 1984.) Contrary to the stereotyped ideas, there are suggestions that supplementary androgens could control prostate cancer (Umekita, et al., 1996), and that antagonists to prolactin and estrogen might be appropriately used in hormonal therapy"
- 1998 - May Ray Peat's Newsletter
0 upvotes"By the age of 50, men often show an excess of both prolactin and estrogen, and a deficiency of thyroid and testosterone. This is the age at which enlargement of the prostate often becomes noticeable."
- 1998 - May Ray Peat's Newsletter
0 upvotes"Another kind of fish, the salmon, which return to fresh water for reproducing, show the other extreme of adaptation to an osmotic problem. After living isotonically in the hypertonic ocean environment, keeping their mineral content and osmolarity lower than sea-water’s, they suddenly have to readapt to the extremely hypotonic fresh water. The secretion of prolactin and glucocorticoid steroids seems to facilitate this sudden adaptation, but those hormones also seem to produce an explosively rapid kind of aging. I think their condition is similar to the Cushingeid symptoms that frequently appear in middle-aged people."
- 1991 - July - Ray Peat's Newsletter
0 upvotes"Hans Selye pointed out that estrogen treatment mimics the first, shock phase of the stress reaction. An excess of estrogen (or any stressor) causes the pituitary to secrete prolactin and ACTH, and both of these hormones act on the ovaries to stop progesterone production,"
- 1990 - October - Ray Peat's Newsletter
0 upvotes"Since tryptophan stimulates prolactin secretions, I thought it might turn out to be just as carcinogenic as reserpine."
- 1990 - May - - Ray Peat's Newsletter
0 upvotes"Although it is important to be aware of the deadly effects of chronic, unopposed exposure to cortisol (and estrogen and prolactin), these hormones which cause atrophy and loss of function in various tissues also have a creative function. I have elsewhere called them the biological erasers, the hormones of new beginnings.!® In the case of cortisol, it might be useful to compare its effects on tissue cells to the process of winnowing wheat, in which the chaff is blown away while the grain is retained. I think there is a mechanism, as proposed by Meerson, in which a functional load preserves the cells and systems which are needed in the present environment, while idle cells are eliminated or reduced by cortisol’s"
- 1988 - August.September - Ray Peat's Newsletter
0 upvotes