Ray Peat on prostate cancer
"There is a clear seasonality in the diagnosis (occurrence) of breast cancer, with a maximum in the spring and a minimum in the fall (Cohen, et al., 1983). The increased discovery in the spring coincides with rising gonadotropins (which are associated with breast and prostate cancer), and the decreased discovery in the fall coincides with higher vitamin D and lower stress hormones."
- May 2016 - Ray Peat's Newsletter
0 upvotes"Since it was known that estrogen treatment was dangerous for men, and that it increases blood clotting and vascular spasms, there ha to be some overriding belief that led to its general use in treating prostate cancer. That belief seems to be that estrogen, the female hormone, opposes testosterone, the male hormone which is responsible for the growth--and therefore for the cancerization—of the prostate gland. Everything is wrong with that sentence, but you can can find every part of the belief present and functioning in the medical literature."
- 1998 - May Ray Peat's Newsletter
0 upvotes"In aging women and men, as the breasts and prostate atrophy, their estrogen/antiestrogen ratio increases."
- 1998 - May Ray Peat's Newsletter
0 upvotes"The pituitary hormones have diverse functons, including effects on epithelial tissues, other than their classical functions. Growth hormone, ACTH (Lostroh and Li, 1957), and ACTH with prolactin (Tullner, 1963) stimulate prostate growth. Prolactin--which is increased by estrogen--stimulates growth of the rats lateral prostate (Holland and Lee, 1980), and stimulates the growth of human prostate epithelial cells in vitro (Syms, et al., 1985)."
- 1998 - May Ray Peat's Newsletter
0 upvotes"Prostate cancer patients who had higher levels of LH and lower testosterone died most quickly. (Harper, et al., 1984.) Also, a high ratio of testosterone to estradiol or of testosterone to prolactin corresponded to better survival (Rannikko, et al, 1981.) Considered separately, patients with higher testosterone levels had a better prognosis than those with lower levels, and patients with lower growth hormone levels did better than those with higher growth hormone levels. (Wilson, et al., 1985.)"
- 1998 - May Ray Peat's Newsletter
0 upvotes"In human prostate slices, several hormones —~ (including insulin, and probably prolactin) stimulated cell division; testosterone did mot,, under these experimental conditions. (McKeehan, et al., 1984.) Contrary to the stereotyped ideas, there are suggestions that supplementary androgens could control prostate cancer (Umekita, et al., 1996), and that antagonists to prolactin and estrogen might be appropriately used in hormonal therapy"
- 1998 - May Ray Peat's Newsletter
0 upvotes"By the age of 50, men often show an excess of both prolactin and estrogen, and a deficiency of thyroid and testosterone. This is the age at which enlargement of the prostate often becomes noticeable."
- 1998 - May Ray Peat's Newsletter
0 upvotes"many of estrogen’s most important actions dont involve the receptors. A direct excitatory action on prostate cells, and indirect actions by way of the pituitary, pancreas, thyroid, adrenal, fatty acids, prostaglandins, histamine and circulation are probably essential parts of the cancenzation process."
- 1998 - May Ray Peat's Newsletter
0 upvotes"Thyroid supplementation, adequate animal protein, trace minerals, and vitamin A are the first things to consider in the prevention of prostate hypertrophy and cancer. Nutritional and endocrine support can be combined with rational anticancer treatments, since there is really no sharp line between different approaches that are aimed at achieving endocrine and immunological balance, without harming anything."
- 1998 - May Ray Peat's Newsletter
0 upvotes