Ray Peat on PUFAs
"Lipid peroxidation was observed in atherosclerotic plaques, and the breakdown products of polyunsaturated fats such as hydroxynonenal, malondialdehyde, and acrolein (from EPA, arachidonic acid, and other highly unsaturated fats in the affected blood vessel are known to attract white blood cells such as macrophages, which accumulate in the plaques."
- September 2018 - Ray Peat's Newsletter
0 upvotes"The age pigment, ceroid or lipofuscin, that’s derived largely from PUFA and associated with the macrophage foam cells in the plaque, accumulates iron (Lee, et al, 1998), and by catalyzing oxidation, creates local hypoxia, leading to lactic acid production, contributing to an inflammatory process. The products of lipid peroxidation, such as azelaic acid (Riad, et al., 2018), along with lactate, lead to the calcification of tissue."
- September 2018 - Ray Peat's Newsletter
0 upvotes"Combined with the unstable polyunsaturated fats, cholesterol can’t perform its normal functions. The unstable polyunsaturated fats inactivate the corrective (ABCA) protein that removes the damaged form of cholesterol"
- September 2018 - Ray Peat's Newsletter
0 upvotes"While there is still great reluctance to acknowledge the carcinogenic nature of PUFA, results such as this have motivated the drug industry to consider using their ACAT inhibitors (blocking the attachment of PUFA to cholesterol) for treating cancer."
- September 2018 - Ray Peat's Newsletter
0 upvotes"The polyunsaturated fatty acids, by being combined with the normally protective cholesterol, convert it into a sort of toxin, a disorganizing factor, leading to neurodegeneration, hardening of the arteries, cataracts, chronic kidney disease, and cancer."
- September 2018 - Ray Peat's Newsletter
0 upvotes"When the diet lacks the polyunsaturated fatty acids, the liver synthesizes saturated fatty acids, and exports its cholesterol mainly in combination with palmitate, which doesn’t promote lipid peroxidation, or in the non-esterified free form."
- September 2018 - Ray Peat's Newsletter
0 upvotes"A lifetime of accumulating PUFA progressively degrades the liver’s protective functions, but those functions can gradually be restored by providing carbohydrates and saturated fats without the polyunsaturated fats, along with some of the factors that have been depleted along with free cholesterol, especially pregnenolone and progesterone."
- September 2018 - Ray Peat's Newsletter
0 upvotes"Leaves contain many substances that can be harmful and that interfere with the digestion of protein and other nutrients, for example tannins and polyunsaturated fatty acids."
- September 2017 - Ray Peat's Newsletter
0 upvotes"Polyunsaturated oils inhibit the immune system and so probably suppress symptoms. The steroids (e.g., progesterone) and thyroid hormones normalize the immune system when they are present in normal amounts."
- Nutrition For Women
0 upvotes"Altitude and a milk based diet are obviously two important thermogenic factors that slow the accumulation of harmful adaptations, but there are many other controllable factors that could extend longevity even more. Reducing inflammatory factors is important, and personal choices can make a big difference, for example choosing easily digestible foods to reduce endotoxin, avoiding the polyunsaturated fatty acids that interfere with cell respiration and form inflammatory prostaglandins, avoiding antioxidant supplements that create a reductive excess, and choosing foods that contain antiinflammatory-thermogenic compounds, such as citrus fruits with their high content of flavonoids that support cell respiratory functions."
- November 2020 - Ray Peat's Newsletter
0 upvotes"The age pigment, lipofuscin, is produced by oxidation of polyunsaturated lipids. The polyunsaturated fatty acids, that accumulate with age, have been known for about 80 years to be the main source of this material. These fatty acids inhibit the synthesis of cholesterol"
- November 2018 - Ray Peat's Newsletter
0 upvotes"Besides eliminating polyunsaturated fats (n-3 and n-6) from the diet to reduce the formation of cholesterol esters and to reduce the decline of cholesterol synthesis with aging, supplementing with progesterone is a way to reduce the formation of esters (Synouri-Vrettakou and Mitropoulos, 1983; Miller and Melnykovych, 1984; Jeng and Klem, 1984; Mulas, et al., 2011; Anchisi, et al., 2012). Lidocaine is another inhibitor of cholesterol ester formation (Bell, 1981; Bell, et al., 1982) that is probably useful in some degenerative conditions."
- November 2018 - Ray Peat's Newsletter
0 upvotes"the accumulating PUFA function as amplifiers of the cellular stress reactions."
- November 2017 - Ray Peat's Newsletter
0 upvotes"Some of the factors that cause atrophy of the thymus gland include cortisol and other glucocorticoid hormones, estrogen, prostaglandins, polyunsaturated fatty acids, lipid peroxidation, nitric oxide, endotoxin, hypoglycemia, and ionizing radiation. Progesterone and thyroid hormone support restoration of the thymus gland, providing protection by opposing all of those agents of atrophy. An increase of sugar in the diet can correct some of the metabolic changes of aging"
- November 2016 - Ray Peat's Newsletter
0 upvotes"‘When cells are respiring vigorously, all of the oxygen reaching the mitochondria is immediately used, so the oxygen concentration near the respiratory enzymes is close to zero. If something interferes with the mitochondrial oxygen consumption (for example lack of thyroid hormone or the presence of too much polyunsaturated fat, or nitric oxide, or carbon monoxide), the local oxygen concentration increases, because it isn’t being used."
- March 2021 - Ray Peat's Newsletter
0 upvotes"The rise of free fatty acids in the serum during the night coincides with a high rate of turnover of the brain’s phospholipids. Polyunsaturated fatty acids are preferentially liberated from fat stores, in proportion to their degree of unsaturation (Raclot, 2003; Conner, et al., 1996), so their interchange with the brain’s lipids means that each night the brain will become enriched with the highly unsaturated fats that are most susceptible to lipid peroxidation."
- March 2018 - Ray Peat's Newsletter
0 upvotes"As our tissues accumulate polyunsaturated fats with aging, the production of prostaglandins becomes greater, and the balance is less likely to be fully repaired."
- March 2017 - Ray Peat's Newsletter
0 upvotes"With aging, iron and the polyunsaturated fats accumulate in the brain. Estrogen slows the removal of dopamine, increasing its opportunity to react toxically with iron and highly unsaturated fats, especially arachidonic acid and DHA; it also tends to increase the formation of prostaglandins and nitric oxide. Progesterone’s opposite effects probably account for the lower prevalence of Parkinson’s disease in women than in men."
- March 2017 - Ray Peat's Newsletter
0 upvotes"free fatty acids, especially when they are polyunsaturated, are toxic to the brain, increasing inflammation and blocking energy metabolism."
- March 2016 - Ray Peat's Newsletter
0 upvotes"Keeping energy efficiency high, while reducing wasteful excitations, has a long history in health optimization. Avoiding excessive polyunsaturated fats and phosphate in the diet, and regularly getting the essential nutrients needed to maintain thyroid and progesterone production, is simple. Choosing foods that contain substances that protect against the many known pro-inflammatory, age-accelerating processes is relatively simple—citrus fruits, for example, contain a great variety of substances related to nobiletin, naringin, fisetin, and quercetin,"
- January 2021 - Ray Peat's Newsletter
0 upvotes"As the proportion of polyunsaturated fatty acids increases with aging, some arachidonic acid becomes incorporated into the brain, and, especially during the night, the highly unsaturated fatty acids amplify the excitatory processes, including the formation of prostaglandins and other inflammation-producing compounds."
- January 2017 - Ray Peat's Newsletter
0 upvotes"tamin E deficiency or PUFA excess, by ionizing radiation, by oxygen deprivation, or by aging. All of these conditions involved interference with, or decreased activity of, the crucial respiratory enzyme, cytochrome C oxidase."
- January 2016 - Ray Peat's Newsletter
0 upvotes"a person relatively free of PUFA will be likely to recover very quickly from prolonged stress."
- Email Response by Ray Peat
0 upvotes"Estrogen and PUFA create insulin resistance, and the resulting state of diabetes and stress de-energizes tissues,"
- 2001 - February
0 upvotes"By the simple process of avoiding the antithyroid substances, especially the polyunsatured fatty acids, the degenerative processes discussed here will be minimized."
- 1999 - December- Ray Peat's Newsletter
0 upvotes"Decades ago, unsaturated oils were found to lower cholesterol. However, studies showed that adding the polyunsaturated oils to the diet didnt prevent death from heart disease, but that it did increase cancer deaths."
- 1991 - April - Ray Peat's Newsletter
0 upvotes